Using patient-collected clinical samples and sera to detect and quantify the severe acute respiratory syndrome coronavirus (SARS-CoV)
Identifieur interne : 003556 ( Main/Exploration ); précédent : 003555; suivant : 003557Using patient-collected clinical samples and sera to detect and quantify the severe acute respiratory syndrome coronavirus (SARS-CoV)
Auteurs : Zhongping He [République populaire de Chine] ; Hui Zhuang [République populaire de Chine] ; Chunhui Zhao [République populaire de Chine] ; Qingming Dong [République populaire de Chine] ; Guoai Peng [République populaire de Chine] ; Dominic E. Dwyer [Australie]Source :
- Virology Journal [ 1743-422X ] ; 2007.
Descripteurs français
- KwdFr :
- ARN viral (analyse), ARN viral (génétique), Adulte, Adulte d'âge moyen, Fèces (virologie), Humains, Pharynx (virologie), Pneumopathie virale (virologie), Pneumopathie virale (épidémiologie), RT-PCR, Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Sérum (virologie), Virus du SRAS (isolement et purification).
- MESH :
- analyse : ARN viral.
- génétique : ARN viral.
- isolement et purification : Virus du SRAS.
- virologie : Fèces, Pharynx, Pneumopathie virale, Syndrome respiratoire aigu sévère, Sérum.
- épidémiologie : Pneumopathie virale, Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Humains, RT-PCR.
English descriptors
- KwdEn :
- Adult, Feces (virology), Humans, Middle Aged, Pharynx (virology), Pneumonia, Viral (epidemiology), Pneumonia, Viral (virology), RNA, Viral (analysis), RNA, Viral (genetics), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (isolation & purification), Serum (virology), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , analysis : RNA, Viral.
- epidemiology : Pneumonia, Viral, Severe Acute Respiratory Syndrome.
- chemical , genetics : RNA, Viral.
- isolation & purification : SARS Virus.
- virology : Feces, Pharynx, Pneumonia, Viral, Serum, Severe Acute Respiratory Syndrome.
- Adult, Humans, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Severe acute respiratory syndrome (SARS) caused a large outbreak of pneumonia in Beijing, China, in 2003. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect and quantify SARS-CoV in 934 sera and self-collected throat washes and fecal samples from 271 patients with laboratory-confirmed SARS managed at a single institution.
SARS-CoV detection rates in sera were highest in the first 9 days of illness, whereas detection was highest in throat washes 5–14 days after onset of symptoms. The highest SARS-CoV RT-PCR rates (70.4–86.3%) and viral loads (log10 4.5–6.1) were seen in fecal samples collected 2–4 weeks after the onset of clinical illness. Fecal samples were frequently SARS-CoV RT-PCR positive beyond 40 days, and occasional sera still had SARS-CoV detected after 3 weeks of illness.
In the context of an extensive outbreak with major pressure on hospital resources, patient self-collected samples are an alternative to nasopharyngeal aspirates for laboratory confirmation of SARS-CoV infection.
Url:
DOI: 10.1186/1743-422X-4-32
PubMed: 17386116
PubMed Central: 1851004
Affiliations:
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institution-id-type="ISNI">000000040369153X</institution-id><institution>Capital University of Medical Sciences Affiliated Beijing YouAn Hospital,</institution></institution-wrap>Beijing, 100054 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Zhuang, Hui" sort="Zhuang, Hui" uniqKey="Zhuang H" first="Hui" last="Zhuang">Hui Zhuang</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.11135.37</institution-id><institution-id institution-id-type="ISNI">0000000122569319</institution-id><institution>Department of Microbiology,</institution><institution>Peking University Health Science Center,</institution></institution-wrap>Beijing, 100083 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, 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Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Guoai" sort="Peng, Guoai" uniqKey="Peng G" first="Guoai" last="Peng">Guoai Peng</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413996.0</institution-id><institution>Beijing Ditan Hospital,</institution></institution-wrap>Beijing, 100011 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Dwyer, Dominic E" sort="Dwyer, Dominic E" uniqKey="Dwyer D" first="Dominic E" last="Dwyer">Dominic E. Dwyer</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead</wicri:regionArea><wicri:noRegion>Westmead</wicri:noRegion></affiliation></author></analytic><series><title level="j">Virology Journal</title><idno type="eISSN">1743-422X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Feces (virology)</term><term>Humans</term><term>Middle Aged</term><term>Pharynx (virology)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (virology)</term><term>RNA, Viral (analysis)</term><term>RNA, Viral (genetics)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (isolation & purification)</term><term>Serum (virology)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>ARN viral (génétique)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Fèces (virologie)</term><term>Humains</term><term>Pharynx (virologie)</term><term>Pneumopathie virale (virologie)</term><term>Pneumopathie virale (épidémiologie)</term><term>RT-PCR</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Sérum (virologie)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Pneumonia, Viral</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fèces</term><term>Pharynx</term><term>Pneumopathie virale</term><term>Syndrome respiratoire aigu sévère</term><term>Sérum</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Feces</term><term>Pharynx</term><term>Pneumonia, Viral</term><term>Serum</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Pneumopathie virale</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Middle Aged</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Humains</term><term>RT-PCR</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Severe acute respiratory syndrome (SARS) caused a large outbreak of pneumonia in Beijing, China, in 2003. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect and quantify SARS-CoV in 934 sera and self-collected throat washes and fecal samples from 271 patients with laboratory-confirmed SARS managed at a single institution.</p></sec><sec><title>Results</title><p>SARS-CoV detection rates in sera were highest in the first 9 days of illness, whereas detection was highest in throat washes 5–14 days after onset of symptoms. The highest SARS-CoV RT-PCR rates (70.4–86.3%) and viral loads (log<sub>10</sub> 4.5–6.1) were seen in fecal samples collected 2–4 weeks after the onset of clinical illness. Fecal samples were frequently SARS-CoV RT-PCR positive beyond 40 days, and occasional sera still had SARS-CoV detected after 3 weeks of illness.</p></sec><sec><title>Conclusion</title><p>In the context of an extensive outbreak with major pressure on hospital resources, patient self-collected samples are an alternative to nasopharyngeal aspirates for laboratory confirmation of SARS-CoV infection.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Liang, W" uniqKey="Liang W">W Liang</name></author><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name></author><author><name sortKey="Guo, J" uniqKey="Guo J">J Guo</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="He, X" uniqKey="He X">X He</name></author><author><name sortKey="Zhou, W" uniqKey="Zhou W">W Zhou</name></author><author><name sortKey="Chin, Dp" uniqKey="Chin D">DP Chin</name></author><author><name sortKey="Schuchat, A" uniqKey="Schuchat A">A Schuchat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name></author><author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name></author><author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Urbani, C" uniqKey="Urbani C">C Urbani</name></author><author><name sortKey="Corner, Ja" uniqKey="Corner J">JA Corner</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Rollin, Pe" uniqKey="Rollin P">PE 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Poon</name></author><author><name sortKey="Lam, Hy" uniqKey="Lam H">HY Lam</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Seto, Wh" uniqKey="Seto W">WH Seto</name></author><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="He, Zhongping" sort="He, Zhongping" uniqKey="He Z" first="Zhongping" last="He">Zhongping He</name></noRegion><name sortKey="Dong, Qingming" sort="Dong, Qingming" uniqKey="Dong Q" first="Qingming" last="Dong">Qingming Dong</name><name sortKey="He, Zhongping" sort="He, Zhongping" uniqKey="He Z" first="Zhongping" last="He">Zhongping He</name><name sortKey="Peng, Guoai" sort="Peng, Guoai" uniqKey="Peng G" first="Guoai" last="Peng">Guoai Peng</name><name sortKey="Zhao, Chunhui" sort="Zhao, Chunhui" uniqKey="Zhao C" first="Chunhui" last="Zhao">Chunhui Zhao</name><name sortKey="Zhuang, Hui" sort="Zhuang, Hui" uniqKey="Zhuang H" first="Hui" last="Zhuang">Hui Zhuang</name></country><country name="Australie"><noRegion><name sortKey="Dwyer, Dominic E" sort="Dwyer, Dominic E" uniqKey="Dwyer D" first="Dominic E" last="Dwyer">Dominic E. Dwyer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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